James,
At the moment I'm using it on the clean channel of my Peavey Classic 30. The tone controls are very efficient so be sure to try out different settings. It's definitely better than the tube screamer I used to have. Using it together with the TCO-1 compressor I get a really singing tone with great sustain. I will experiment using it on the overdrive channel of my amp as well, I haven't had time to do that yet. I will now get rid of my Boss DS-2 and Korg programmable classic overdrive. I find the Tokai TMD, TOD and TDS overdrive/distortions so good I don't need any other distortions any more. They also sound good together with my old Peavey Bandit 65 transistor amp. I mostly use my Tokai strat or Fender USA/Squier Japan frankenstrat, both have SD Little '59 humbuckers in the bridge position and single coils mid/neck.
Michael